Cell signaling

Our scientists significantly contributed to the deconvolution of the mechanisms of signal transduction, such as RTK and endocytosis, which is of pivotal importance for the complete understanding of the biological issues and crucial to provide powerful tools to hinder this mechanism. More recently, we have been focusing on the characterization of the cell signaling triggered by microenvironmental signals in cancer cells.

Cloning of the Shc gene and role in signal transduction from activated tyrosine kinases to Ras and stress responses

Nature 1999; Cell 2005.

Molecular dissection of novel mechanisms of RTK-mediated signal transduction

Nat Struct Biol 1997; Nature 1999, 2000 and 2004; Nat Cell Biol 2004 (i), 2004 (ii) 2004 (iii); Nat Cell Biol 2005 and 2006; Cell 2006 and 2008; PLoS Biol 2010 and 2011; Dev Cell 2014 (i), 2014 (ii); Nat Med 2016.

Endocytosis as organizer of the cellular masterplan and its involvement in signal- and-spaceresolved signaling

Genes Dev 1997; Nature 1998 and 2010; Cell 2001, 2005 and 2006; Nat Cell Biol 2001; PNAS 2005; Dev Cell 2008; J Cell Biol 2014; Elife 2016; Cancer Cell 2017.

Crosstalk between N-CAM and FGFRs in ovarian cancer

Nat Cell Biol 2001; J Cell Biol 2009; EMBO Mol Med 2011.

Reciprocal regulation of the Autophagy/Apoptotic Beclin/Mcl proteins during melanomagenesis

Nature Comm 2014.

Targeting of the Sumoylation pathway by oncoviral Proteins

Mol Cell 2004; MCB 2007; PNAS 2013; PlosPathogens 2017.

Identification of the signaling properties of ubiquitin

Nature 2002; Nat Rev Mol Cell Biol 2003; Cell 2006; Nat Cell Biol 2003 and 2006; EMBO J 2013; Science 2017.

Cell signalling