Call for the selection of a biostat

  1. OBJECT

A comparative selection procedure, based on qualifications and interview, is launched for the awarding of a research grant, lasting 12 months, for The Molecular and Pharmaco-Epidemiology Unit of the Department of Experimental Oncology, for an amount of 25.000 euros, aimed at increase the knowledge of a biostatistician.

  1. BACKGROUND

Our group work on primary and secondary cancer prevention projects, as well as on prognostics and predictive biomarkers of solid tumors (e.g. MC1R polymorphisms and neutrophil-to-lymphocyte ratio, Adiponectin etc.).

We are interested in investigating the polygenic nature of cancer, by studying the various forms of potential interactions between genetic, phenotypic and environmental factors and their impact on both cancer development and prognosis. The advancement in technologies now allows the production of large numbers of data, generally classified as “-omics”, that need specific approach of statistical analysis. The translation of laboratory results in clinical setting is often complex and needs an integration of different information on a wide spectrum of clinical, molecular, epidemiological and lifestyle factors.

We have reached a great expertise in conducting studies related to skin cancer, especially melanoma. We are interested in investigating the role of microbiome and biomarkers, such as vitamin D serum level, GC binding protein and VDR polymorphisms, in association with skin cancer risk and prognosis.

We are also investigating the association between candidate single nucleotide polymorphisms (SNPS) with skin cancer risk, with particular attention to their direct and indirect effect in skin cancer risk and to gene-environment interaction. This is of particular importance for assessing preventive strategies that could be applied in a clinical context and be therefore directed to specific at risk categories basing on both genetic and clinical/epidemiological risk factors.

Our projects aimed to integrate and assess the importance of epidemiological factors in translational and clinical research. With our researches, we would like to create the basis of personalized prevention and therapeutic programs for cancer that will integrate molecular, genetics and epidemiological risk factors.

Our group is seeking a motivated biostatistician to improve his knowledge on statistical analyses within the multiple projects in the field of skin cancer, in collaboration with the Division of Melanoma, Sarcoma and Rare Cancer, directed by Dr. Paola Queirolo. The candidate will be based at the IEO in Milan.

During the research grant the candidate will increase his/her experience on:

  • Perform univariate and multivariate analyses of clinical and biological data, with possible application of machine learning approaches for –omics data.
  • Participate in the study design and interpretation of results.
  • Contribute to statistical analysis process optimization and standardization.
  • Participate to the development of scientific databases and their application in clinical studies.
  • Writing study protocols and documentation.
    • Writing scientific papers.
  1. ESSENTIAL REQUIREMENTS

Those who possess the following requirements and/or qualifications can participate in the selection:

  • BSc. or MSc. in biostatistics-related subject (statistics, biology, bioinformatics, mathematics, physics).
  • Programming skills (SAS, R, preferable).
  • Good English level.

The following qualifications represent an added value:

  • Ph.D. in Biostatistics or Medical Statistics or equal experience.
  • Experience with -omics data analysis.
  • Prior experience working with large-scale datasets using high performance computing environments is desirable.
  • Experience with skin cancer studies and epidemiology.
  • Experience with database construction and maintenance.
  1. TRAINING PROJECT

The selected person will increase the knowledge on the following activities:

  • Perform univariate and multivariate analyses of clinical and biological data, with possible application of machine learning approaches for –omics data.
  • Participate in the study design and interpretation of results.
  • Contribute to statistical analysis process optimization and standardization.
  • Participate to the development of scientific databases and their application in clinical studies.
  • Writing study protocols and documentation.
  • Writing scientific papers.
  1. APPLICATION FOR PARTICIPATION

The application for participation in the selection must be submitted on the website https://www.research.ieo.it/careers-and-jobs/ , by clicking on "apply" on the page dedicated to the publication of the vacancy for the scholarship described above. For the application, to be considered valid, it is required to fill in all mandatory fields (first name, last name, e-mail, date of birth, place of birth, street and number, country, city, university, last degree) Any candidate who submits an application form that is not suitable in the terms and forms described above is automatically excluded from the selection process.

Deadline for application:15/04/2022

  1. EXAMINATION BOARD

In evaluating the candidates, objective and predetermined criteria will be used, such as the curriculum vitae and the interview to assess compliance with the requirements established by the Director of the Medical Oncology Division of Melanoma, Sarcome and Rare Tumors of the European Institute of Oncology, Dr. Paola Queirolo, and by the Group Leader, Head of the Research Project, Dr. Sara Gandini. The commission was chosen for its expertise in oncology on melanoma, sarcoma and rare tumors as well as for its expertise in biostatistics.

The comparative assessment is carried out on the basis of qualifications and interview. The qualifications admitted to evaluation are:

- curriculum vitae.

The selection board proceeds in a preliminary session to establish the criteria on the basis of which it will proceed to evaluate the qualifications and the interview, in order to ascertain the greater consistency of personal preparation with respect to the required characteristics, taking into account the highly qualified nature of the service.

The commission will evaluate the candidates' qualifications before the interview is completed.

The judging commission can assign, for the qualifications, the maximum score of 20 (twenty) points and, for the interview, the maximum score of 40 (forty) points;
The interview is passed with a grade of at least 42/60.
During the interview, the candidate's curriculum vitae, his academic training experience and his motivation to continue training in this sector will be deepened.

The candidate will be notified of the day of the interview, the date and the place where he or she will have to go.

If on the date established for the interview the epidemiological emergency situation from COVID-19 still persists, the same will take place remotely, via Microsoft Team. The link for the electronic connection will be communicated to the email address provided in the application form.

At the outcome of the comparative procedure, the selection board draws up the merit ranking, according to the descending order of the points of the overall assessment attributed to each candidate.
If two or more candidates will have the same score at the end of the selection, they will undergo a second in-depth interview.

  1. CONTRACT: EFFECTIVENESS AND CONSIDERATION

The selected candidate will be notified by e-mail of the assignment of the scholarship and the contract will be activated within 30 days. The ranking of candidates will in any case be made public at the end of the selection process.