Postdoc position - Epigenetic Mechanisms of Cancer

Our laboratory is looking for a post-doc to work on Polycomb-related mechanisms of transcriptional repression and chromatin integrity in the control of cellular identity, decrypting the molecular details of related oncogenic mechanisms.

Candidate profile

The candidate must be highly motivated with excellent communication skills and proven knowledge in the fields of molecular and cellular biology. Candidates with deep expertise with transcription, chromatin and epigenetics and or with expertise in epigenomics, proteomics and genetic engineering are particularly encouraged to apply. Fluent communication skills in English are required.

Work environment

The Pasini’s laboratory operates within the Department of Experimental Oncology of the European Institute of Oncology (IEO) located in Milan, Italy (https://www.research.ieo.it/).

The candidate will work in close relationship with the computational scientists of the laboratory embedded with the researchers of the European Institute of Oncology (IEO, Milan). The candidate will have access to all the required infrastructures to pursue the research activity including fully equipped laboratories and state-of-art technological units.

The IEO is one of the leading research institutes in Italy. IEO operates as a Comprehensive Cancer Center, linking fundamental and applied research to clinical activities, patient care and clinical trials. The Department of Experimental Oncology (DEO) is currently composed of ~250 scientists working in 20 independent research groups and units. DEO is located within a scientific campus together with two other partner institutions: the FIRC Institute of Molecular Oncology (IFOM) and the Italian Institute of Technology (IIT). The IEO is one of the 13 members of the EU-LIFE alliance to promote excellence in life sciences in Europe (http://eu-life.eu)

IEO is an equal opportunity employer committed to excellence through diversity.

A competitive salary will be offered according to the candidate experience. 

Relevant publications

  • Conway E,, Rossi F., Fernandez-Perez D., Ponzo E., Ferrari K.J., Zanotti M., Manganaro D., Rodighiero S., Tamburri S. and Pasini D. BAP1 enhances Polycomb repression counteracting widespread H2AK119ub1 deposition and chromatin condensation. PMID 34186021. Molecular Cell. 2021
  • Tamburri S., Lavarone E., Fernandez-Perez D., Conway E., Zanotti M., Manganaro D. and Pasini D. Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. PMID 31883952. Molecular Cell. 2020
  • Scelfo A., Fernandez-Perez D., Tamburri S., Zanotti M., Lavarone E., Soldi M., Bonaldi T., Ferrari K. J. and Pasini D. Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities. PMID 31029542. Molecular Cell. 2019
  • Pivetti S., Fernandez-Perez D., D'Ambrosio A., Barbieri C. M., Manganaro D., Rossi A., Barnabei L., Zanotti M., Scelfo A., Chiacchiera F. and Pasini D. Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type-dependent outcomes. PMID 31106267. Science Adv. 2019
  • Lavarone E., Barbieri C. M. and Pasini D. Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity. PMID 30976011. Nature Commun. 2019
  • Chiacchiera F., Rossi A., Jammula S., Zanotti M. and Pasini D. PRC2 preserves intestinal progenitors and restricts secretory lineage commitment. PMID 27585866. EMBO Journal. 2016
  • Chiacchiera F., Rossi A., Jammula S., Piunti A., Scelfo A., Ordonez-Moran P., Huelsken J., Koseki H. and Pasini D. Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/beta-Catenin Transcriptional Activity. PMID 26526724. Cell Stem Cell. 2016

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