IEO PATENT PORTFOLIO
Therapy
SMALL MOLECULES
| Therapeutic use of PCYOX1 inhibitors | |||
| Use of a molecule capable of inhibiting PCYOX1 for use in the treatment and prevention of cancer and metastases. | |||
| Application n. PCT/EP2023/055604 | Priority Date 04/03/2022 | Main Inventors Saverio Minucci Isabella Pallavicini | Status |
| Molecules for use in the treatment of viral infections | |||
| Epigenetic drugs for use in the treatment and/or prevention of a viral infection and method to screen a therapeutic treatment of a viral infection | |||
| Application n. IT-102020000007873 | Priority Date 14/04/2020 | Main Inventor(s) Luca Mazzarella Saverio Minucci Pier Giuseppe Pelicci | Status Available for partnering |
| Compounds and composition for the treatment of tumors | |||
| Compounds blocking homologous recombination (HR) DNA repairing mechanism by disrupting Rad51-BRCA2 interaction | |||
| Application n. PCT/IB2020/061825 | Priority Date 11/12/2019 | Main Inventors Saverio Minucci Giuseppe Pelicci | Status For more information |
| Hect E3 ligase NEDD4 inhibitors and uses thereof | |||
| New E3 ubiquitin-ligase NEDD4 inhibitor molecules and their use for the treatment of oncological and infectious pathologies | |||
| Application n. PCT/EP2020/065372 | Priority Date 03/06/2019 | Main Inventor(s) Sebastiano Pasqualato | Status For more information |
| Therapy and diagnosis of disease characterized by alterations in the DNA damage response | |||
| Activators of PP2A phosphatase, their use for the treatment of oncological pathologies and method to identify eligible patients for PP2A activators-based therapy. | |||
| Application n. PCT/EP2018/063257 | Priority Date 19/05/2017 | Main Inventor(s) Saverio Minucci | Status Available for partnering |
| Reprogramming-based models of neurodevelopmental disorders and uses thereof | |||
| Neuronal cell models based on reprogrammed stem cells from patients with autism spectrum disorders, methods of obtaining them and use of LSD1 inhibitors for their treatment. | |||
| Application n. PCT/EP2015/077659 | Priority Date 26/11/2014 | Main Inventor(s) Giuseppe Testa | Status Available for partnering |
| New LSD1 inhibitor molecules in oncology (7 patent families) | |||
| New small molecules inhibiting LSD1 enzyme for the treatment of oncological diseases alone or in combination with other therapeutic agents | |||
| Application n. PCT/EP2011/055990 PCT/EP2013/075409 PCT/EP2015/062037 PCT/IB2015/001953 PCT/EP2017/062009 PCT/EP2018/060637
PCT/EP2018/072319 | Priority Date 20/04/2010 05/12/2012 30/05/2014 05/09/2014 18/05/2016 26/04/2017
18/08/2017 | Main Inventor(s) Saverio Minucci Mario Varasi Mario Varasi Mario Varasi Mario Varasi Saverio Minucci Pier Giuseppe Pelicci Mario Varasi | |
Biologicals
| Flagellin-related peptides and uses thereof | |||
| Ehancement of antitumor immunity with flagellin-based peptides in melanoma patients undergoing immune checkpoint inhibitor’s therapy | |||
| Application n. EP24164184.4 | Priority Date 18/03/2024 30/07/2024 | Main Inventors Luigi Nezi
| Status For more information |
| Engineered transposase and uses thereof | |||
| An engineered transposase comprising a transposase operably linked to a polypeptide that binds to a component of heterochromatin | |||
| Application n. PCT/EP2022/052915 | Priority Date 05/02/2021 | Main Inventors Sebastiano Pasqualato | Status For more information |
| Antibodies anti-tumor associated antigens and method for obtaining them New tumor-specific antibodies, method for obtaining them and their use in the treatment of oncological pathologies. | |||
| Application n. PCT/EP2019/066217 | Priority Date 19/06/2018 | Main Inventor(s) Pier Giuseppe Pelicci | Status Available for partnering |
| Postbiotic-based composition for treatment of ocular inflammation Metabolic products of Lactobacillus Paracasei for the treatment of conjunctivitis | |||
| Application n. PCT/EP2017/069681 | Priority Date 03/08/2016 | Main Inventor(s) Maria Rescigno | Status Partnered |
Methods and biomarkers
| Method for prognosis of bladder cancer | |||
| A multigene predictor of risk of muscle-invasion for personalized management of non-muscle- invasive bladder cancer (NMIBC) patients. | |||
| Application n. EP24191940.6 | Priority Date 31/07/2024 | Main Inventors Salvatore Pece Daniela Tosoni Giuseppe Renne | Status For more information |
| Method for prognosis of breast cancer | |||
| A PET-surrogate signature that interrogates the metabolic status of breast cancers and independently prognosticates bad clinical outcome. | |||
| Application n. EP24165583.6 | Priority Date 22/03/2024 | Main Inventors Pier Paolo DI Fiore Stefano Confalonieri Bronislava Matoskova | Status For more information |
| A novel isoform of the cell-surface adhesion molecule L1 having high angiogenic activity | |||
| New soluble isoform of L1 adhesion protein and related diagnostic kit for the detection and monitoring of oncological pathologies | |||
| Application n. IT n. 102018000007726 | Priority Date 01/08/2018 | Main Inventor(s) Ugo Cavallaro | Status Available for partnering |
| Use of the expression of specific genes for the prognosis of patients with triple negative breast cancer | |||
| Use of the expression of specific genes for prognostic evaluation in patients with triple negative breast cancer and who have received neoadjuvant chemotherapy | |||
| Application n. PCT/EP2017/066533 | Priority Date 01/07/2016 | Main Inventor(s) Giuseppe Curigliano | Status For more information |
| Methods and kits comprising gene signatures for stratifying breast cancer patients | |||
| Prognostic molecular signature for the evaluation of risk of relapse in patients with ER positive and HER2 negative breast cancer | |||
| Application n. PCT/EP2017/064937 | Priority Date 20/06/2016 | Main Inventors Pier Paolo DI Fiore Salvatore Pece | Status Partnered |
Medical device
| Multifunctional hybrid cellulose nanocrystals-gold nanoplatform and use thereof in medicine | |||
| High-performance, high-quality nanotechnology for applications in the field of precision nanomedicine | |||
| Application n. PCT/IB2023/055515 | Priority Date 31/05/2022 | Main Inventors Saverio Minucci Cristina Garibaldi Roberto Orecchia | Status |