Saverio Minucci

*Email*	[email protected]
*Location*	Building 13 Floor 1st Via Adamello 16, Milano

Member of

Abdel-Aziz AK, Pallavicini I, Ceccacci E, Meroni G, Saadeldin MK, Varasi M, Minucci S

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.

Haematologica, 2019
Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S

Combination of hypoglycemia and metformin impairs tumor metabolic plasticity and growth by modulating PP2A-GSK3β-MCL-1 axis.

Cancer Cell, 2019
Magnani L, Frige G, Gadaleta RM, Corleone G, Fabris S, Kempe MH, Vershure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ER metastatic breast cancer.

Nat Genet, 2017
Elgendy M, Abdel-Aziz AK, Renne SL, Bornaghi V, Procopio G, Colecchia M, Kanesvaran R, Toh CK, Bossi D, Pallavicini I, Perez-Gracia JL, Lozano MD, Giandomenico V, Mercurio C, Lanfrancone L, Fazio N, Nole F, Teh BT, Renne G, Minucci S

Dual modulation of MCL-1 and mTOR determines the response to sunitinib.

J Clin Invest, 2017